 Signet ring cell carcinoma, SRCC, a rare form of gastric cancer, has been found to be characterized by distinct molecular features and an immunosuppressive environment. These findings suggest that SRCC may be more aggressive than other forms of gastric cancer and could potentially benefit from cladeted therapies. This article was authored by Wei Zhujiao, Yin Feijiao, Guan Zhusun, and others.