 Leprosy-related disability is a significant challenge to public health and social and rehabilitation services in endemic countries. This study found that the majority of individuals with leprosy-related disability experienced physical impairment, activity limitations, stigma, discrimination, and social participation restrictions. Additionally, stigma was identified as a major determinant of social participation, highlighting the need for stigma reduction initiatives and socio-economic rehabilitation efforts. This article was authored by Vim H. Van Braeckel, Benjamin Sy-Homming, Hernani Jere, and others.