 Serotonias to liquid ripods were used to prepare a hydroethanolic extract, which showed antioxidant properties due to the presence of biologically active compounds identified by liquid chromatography mass spectrometry. A topical formulation based on liposomes was then developed to improve the applicability of the extract in therapy. Liposomes were characterized as having small size 100nm negative charge minus 13mV and high entrapment efficiency greater than 90% demonstrating both spherical and elongated shapes with oligolamelor structure. Biocompatibility was demonstrated in cells including erythrocytes and representative skin cell lines. The antioxidant activity of the extract was proven by its ability to scavenge free radicals reduce ferric ions and protect skin cells from oxidative damage. This article was authored by Maria DeLuca, Carlo Ignazio Giovanni Taborosso, Ramon Pons, and others.