 Our study has identified three prognostic and screening biomarkers, COL-12A1, COL-5A2, and THBS1, which can be used to predict the progression of gastric cancer. Additionally, we have constructed two CERC-RNA-RNA-RNA regulatory networks and identified 15 hub genes, which are related to extracellular matrix organization and interaction. These findings suggest that CERC-RNAs may serve as potential therapeutic targets for gastric cancer treatment. This article was authored by Jinning Yang, Guoliang Yi, Yang Pingjin, and others.