 Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. Neutrophils are affected by the virus in several ways, including decreased activity of the glycolytic enzyme GAPDH, which leads to alterations in metabolite levels and production of neutrophil extracellular traps and nets. Locking GAPDH activity prevents neutrophil death and net formation, suggesting that this enzyme plays a key role in the pathology of severe COVID-19. This article was authored by Yafeng Li, Jessica S. Hook, Qing Ding, and others.