 This study presents a novel approach for integrating fragile enzymes into a robust porous crystalline structure. The researchers used a pyrene tecton with four formic acid arms to create a hybrid bio-catalyst. These arms allow the pyrene tecton to be dispersable in small amounts of organic solvents, while also allowing it to form hydrogen bonds with other molecules. This allows the pyrene tecton to be linked to an extended supermolecular network around an enzyme in almost organic solvent-free aqueous solutions. The resulting hybrid bio-catalyst has long-range ordered pore channels that can act as gates to filter out the catalytic substrates, increasing the bio-catalytic selectivity. Additionally, the researchers were able to use this hybrid bio-catalyst to develop an electrochemical immunosensor that can detect cancer biomarkers at levels as low as one part per million, PgML. This article was authored by Wei Huang, Haitao Yuan, Huang Chenyang, and others.