 First I'd like to thank the Brain Foundation and the donors for giving us the funding for this award. Myself and the co-investigators also from the University Adelaide, Michael Lardelli and Stephen Peterson are very grateful and appreciative for this funding. So one of the most burning questions for Alzheimer's disease research and also of course for the many, many people affected by this disease is why is there still no effective treatment? Why has there been repeated failure of clinical trials of this disease? So there's more than one answer to that question but in our research group we believe it's because we really still don't have a clear understanding of what is causing this disease. What are the molecular mechanisms underlying the changes that would go on inside an Alzheimer's disease brain? So we know that Alzheimer's disease does take decades to develop and to sort of understand and determine what some of these causative factors might be. We need to make detailed molecular analysis of young brains before they'd go on to develop Alzheimer's and of course it's quite difficult to do in humans and human studies so this is why we need to use animal models. So in our research group to try and help us understand and identify some of these causative factors we've generated zebrafish models that mimic the genetic state of inherited Alzheimer's disease as closely as possible. So essentially we've made mutant models of Alzheimer's disease. So we can look inside the make detailed molecular analysis inside the young brains and then we can also compare this to aged brains to see if the changes are different or if they persist and so this is one of the real benefits of using animal models because we can do this type of aging analysis. So we've already made some detailed molecular analysis of our young brains and we're actually seeing quite dramatic effects on energy production. So energy production is critical as it supports all other brain functions but in this analysis we looked at the whole brain and the brain is actually made up of many different types of cells not just neurons and the energy relationships between these different types of cells can be quite complex. So this project will actually look at the young brains again but we'll look at the single cell level to try and identify how these different cell types are affected in our genetic model of Alzheimer's disease. So when we heard that we received this funding we were really excited because we can use this new technology, this new single cell analysis and so yeah we hope that our results will reveal and contribute to the molecular what's underlying the molecular mechanisms causing Alzheimer's disease and also inform other researchers so they may be our research will help find new molecular targets for drug development. So again thank you very much for this funding.