 A novel pearl powder, peepee, hybrid fish gelatin methacrylate, gelmah, hydrogel scaffold loaded with vascular endothelial growth factor, VEGF, is presented, which has been designed to promote bone regeneration through osteogenesis and angiogenesis. The microfluidic-assisted 3D printing technology allows for precise control of the composition and structure of the hybrid scaffold, while its biocompatibility cell adhesion, and osteogenic differentiation ability make it a promising candidate for clinical applications in bone regeneration. This article is authored by Lee Yong, Lu Fan, Sian Lin, and others.