 Health systems worldwide are facing shortages in health professional workforce. Several studies have demonstrated the direct correlation between the availability of health workers, coverage of health services and population health outcomes. To address this shortage, online e-learning is increasingly being adopted in health professionals education. To inform policymaking, in online e-learning, we need to determine its effectiveness. This article was authored by Pradeep Paul George, Nicos Papakrista, Jose Mottano Bellisario and others.