 The study compares the efficacy and tolerability of pulsed dilaser, PDL, and intense pulsed light in treatment of melasma, finding that both treatments were effective and safe, with vascular endothelial growth factor, VEGF, being a possible mechanism underlying their action on melasma. This article was authored by R. W. M. Hassan, Naswa N. Elfa, Omnia M. Risic, and others.