 The study examines the flow behavior of a liquid-liquid extraction, LLE, process in a serpentine microchannel. It uses a 3D model to simulate the flow of chloroform and water, and compares the results to experimental data. When the flow rates of both liquids are low and similar, a slug flow pattern is observed. As the overall flow rate increases, the slug flow transforms into parallel plug flow or droplet flow. If the aqua flow rate is increased while keeping the organic flow rate constant, a transition from slug flow to either droplet flow or plug flow occurs. The study then characterizes and depicts the flow rate patterns in the serpentine microchannel. These findings can be used to optimize the design of microfluidic devices for various applications and demonstrate the applicability of computational fluid dynamics, CFD, simulations in studying the behavior of fluids in microfluidic devices. This article was authored by Eunice Umini, Valeola Gazanfuri, Mehron Hadery, and others. We are article.tv, links in the description below.