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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 5.1: Putting the pieces together - Genome Sequencer- Part 1 01:35 Outline 02:28 Motivation for Genome Sequencing 05:13 Extraordinary Progress 06:58 Solid-state ICs vs. Biochips 07:57 Outline 07:58 Conventional Sequence-by-Synthesis 13:21 Recall: Theory of pH-sensing 15:01 pH-based Genome Sequencers 18:52 Sequencing by Synthesis 20:27 Modeling Approach 23:13 Model Validation 24:50 How does the pH-based sequencer 27:45 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.