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Electron Tunneling in Respiratory Complex I

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Uploaded on Nov 30, 2010

Complex I (NADH:ubiquinone oxidoreductase) is a key enzyme in the respiratory electron transport chain, which transfers electrons over 90 Å along seven Fe/S clusters. Complex I defects are the cause of many neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease. We for the first time identified distinct tunneling pathways, key protein residues, and proposed a unique role of internal water as a mediator.

T. Hayashi, A. Stuchebrukhov, PNAS, 107, 19157 (2010)
http://www.pnas.org/content/107/45/19...

Prof. Alexei Stuchebrukhov Group
http://stuchebrukhov.ucdavis.edu/ET_i...

Tomoyuki Hayashi
http://www.thayashi.com/research/

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