 Pyruvate kinase M2, PKM2, a key enzyme in glycolysis, plays a critical role in regulating reactive oxygen species, ROS, production, and microbial killing in neutrophils. This study found that PKM2 is essential for ROS production and bacteria killing in neutrophils, as well as for the proper functioning of the glycolytic pathway. This article was offered by Juliana Eschicola-Cowahisa, Carlos Heroji Hiroki, Camila Merles, DeSousa Silva, and others.