 The study found that a specific genetic variant in the TNFAIP3 gene, RS14653 for 657A, G, was more common among Hispanics compared to Caucasians. Additionally, this variant was associated with decreased function of the TNFAIP3 protein, which is involved in regulation of inflammatory responses. The study also identified another variant, RS2230926, T, G, which was more common among African-Americans than Caucasians. This variant was also associated with reduced functionality of the TNFAIP3 protein. These findings suggest that these variants may be important contributors to differences in susceptibility to certain immune-related diseases between different ethnicities. This article was authored by Bing Zhong, Brooke Naomey-Nokamura, Aurea Pellman, and others.