 This study proposes a novel approach to treating immunologically cold tumours by using a single-agent mRNA nanomedicine-based strategy to trigger pyruptosis. Pyruptosis is a recently discovered mechanism in cancer immunotherapy which can be used to enhance anti-tumour immunity. This study found that this method can convert cold tumours into hot tumours, creating a positive feedback loop to promote anti-tumour immunity. Furthermore, it was shown that this method can also increase the efficacy of anti-PD1 immunotherapy, making it more effective at treating tumours. This study provides a potential solution for treating immunologically cold tumours and could lead to improved treatment outcomes. This article was authored by Fengqiao Li, Xueqing Zhong, William Ho, and others.