 Resistance starch 2, RS2, which is a type of dietary fiber, has been shown to be beneficial for people suffering from irritable bowel syndrome, IBS. However, there have been few studies on its tolerance in humans. This study looked at the tolerance of RS2, sugarcane bagasse, and their combination in IBS patients and healthy controls. The results showed no significant difference in overall symptoms between the groups, suggesting that RS2 can be safely used by IBS patients. Additionally, one IBS patient experienced mild symptoms when taking the lowest dose of RS2 combined with sugarcane bagasse, while another had severe symptoms when taking the highest dose of sugarcane bagasse alone. These findings suggest that RS2 should be taken in moderate amounts, as higher dosages could cause adverse reactions in some individuals. This article was authored by Daniel So, Chukayou, Peter Argybson, and others.