 Calcium phosphate ceramics are widely used in orthopedics, dentistry, and maxillofacial surgeries as bone replacements and regenerations. The success of these treatments depends on the ability of the ceramics to degrade and resorb over time, allowing for the formation of new bone tissues. Factors such as cellular activity, cytokines, and pH levels can influence this process. Cells such as macrophages, fibroblasts, and osteoblasts can all contribute to the degradation of the ceramic material either directly or indirectly through the release of cytokines and other growth factors. Additionally, changes in pH levels can cause demineralization of the ceramic material, leading to its eventual resorption by osteoclasts. This article was authored by Zishan Sheikh, Mohamed Nur Abdullah, Ahmed Abdallah Hanafi, and others.