 In this study, we found that moderate hypoxemia and hypoglycemia were common among children seeking out patient care in Malawi. While the prevalence of severe hypoxemia and hypoglycemia was low, moderate levels were not uncommon and could potentially be useful as an objective tool to determine referral needs. Additionally, IMCI Danger Signs identified hypoglycemic children, but results highlight the challenge to detect hypoxemia. Further studies should explore case management strategies for moderate hypoxemia and hypoglycemia. This article was authored by André Thunberg, Bida Welles-A-Dutza, Everlisto Fiery, and others.