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Ion Torrent Q2 Update: New Cancer Panel and Inherited Disease Panel

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Published on Jun 5, 2012

Dr. Andy Felton gives a report on the new and updated products coming from Ion Torrent in the second quarter, including the Ion AmpliSeq Comprehensive Cancer Panel, the Ion AmpliSeq Inherited DIsease Panel and the new Ion Reporter Software.

Here is a short excerpt from the interview with Dr. Felton:
We have a significant expansion of Ion Ampliseq Portfolio that's going to be really exciting. First of all, we've got our brand new set of panels the first of which is called the Ion AmpliSeq™ Comprehensive Cancel Panel. That allows us to survey over 400 genes for cancer research. The second is called the Ion AmpliSeq™ Inherited Disease Research Panel, and that's surveying over 300 genes for inherited diseases, Mendelian, common Mendelian diseases. And we have an expansion of our Ion Ampliseq design in our product line, and this is for any custom panel. And we can now design panels for up to targets of one mega base in size. And the last piece of this puzzle is really a solution for the bioinformatics problem. So the customers are experiencing a deluge of data from Next Generation sequences, and what they really need is a solution that allows them to get to the variants and the meaning behind those variants and the mutations very quickly. Ion Reporter is going to do that for them.
Ion Ampliseq is a technology we developed inside Ion Torrent and launched late last year. And what it fundamentally us to do is very highly multiplexed PCR reactions. And as an example, our comprehensive cancer panel actually comes in four tubes and each tube contains 4,000 amplicons. So we're multiplexing those amplicons to go down a single reaction. You get the specificity and the uniformity of PCR by using the Ampliseq approach. So you get very good coverage of your target regions. You have a very fast workflow. The library is constructed in just three and a half hours. And then, the whole process can be done inside a single day from DNA to the variant calling.
With our Ion Reporter solution now we can do the variant calling in just half an hour or so, and actually derive the biological significance of those mutations that you're seeing by taking that Ion Reporter data and blasting it against other data bases, external data bases that gives us the biological mean. This really unlocks the potential of many samples around the world that are stored in repositories in the form of formal and fixed paraffin embedded tissues.

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