 Our study aimed to identify factors that contribute to delays in the IRB review process. We found that certain types of IRB reviews, as well as whether the protocol falls under VA purview, can affect the amount of time it takes for a protocol to be approved. Additionally, we discovered that certain staff members take longer than others to complete their portion of the review. These findings suggest that there may be ways to streamline the IRB review process by focusing on these areas. To address these issues, we implemented changes to the IRB workflow and staffing structure. This includes assigning more experienced staff to complex protocols, providing additional training to staff, and creating a standardized timeline for each step of the review process. By making these adjustments, we hope to reduce the overall time it takes for protocols to be approved. This article was authored by Kimberley Shinbill, Hicham Song, Nichelle Elcock, and others.