 This report provides an overview of current cancer epidemiology from official databases, including frequency, mortality, and survival expectancy of the 15 leading types of cancers worldwide. Cancer poses the highest clinical, social, and economic burden in terms of cost-specific disability-adjusted life years, dailies, among all human diseases. The overall risk of developing cancer is 20.2%, with lung, breast, and prostate being the most frequent cancers. Lung and liver are the three most deadly cancers, while prostate and thyroid have the best prognosis. This report aims to provide a foundation for addressing health care interventions aimed at preventing, diagnosing, and managing cancer globally. This article was authored by Camilla Mediutzi and Giuseppe Lippi.