 This study identified a novel lectin biomarker, UI, which can be used to detect and diagnose colorectal cancer, CRC. This lectin was conjugated with upconversion nanoparticles and used to target CRC cells. It was then used to create multimodal imaging probes that could be used to detect and diagnose CRC. This article was authored by Roh-Rong Tian, Huazhong, Hongdaqian, and others.