 Robust scientific evidence supports the significant impact of two rotavirus, RV, vaccines worldwide on RV disease burden. Improving vaccination coverage may lead to better disease control, and research continues into new RV vaccines to improve accessibility and effectiveness in high mortality settings. Informed decision making is crucial when choosing a vaccine for immunization due to the range of available options, with future investigations needed to evaluate their performance in real world settings. This article was offered by Volkaveta, Robert C. Gardner, Serge Debruss, and others.