 Oxidative stress is a major contributor to the development of diabetes mellitus. It can be caused by an imbalance between the body's natural antioxidants and free radicals, leading to a variety of complications including stroke, neuropathy, retinopathy, and nephropathy. Biomarkers of oxidative stress in diabetes mellitus include lipids, proteins, DNA damage, glutathione, catalase, and superoxide dismutase. This article was authored by Asmetola, Abad Khan, and Ismail Khan.