 uremic paritis is a common and bothersome symptom in patients with end-stage renal disease. It is characterized by itchiness and discomfort, which can significantly impact quality of life. Research suggests that this condition may be caused by a combination of factors, such as skin biology, the nervous system, and inflammation. Treatment options include topical creams, phototherapy, and systemic medications, but there is still much to learn about how best to manage this condition. This article was authored by Mei Jukou, Yusin Peng, and Hanyan Wu.