 Acrimansia myosinifela, A. myosinifela, is a gut micropstrain that has been gaining attention due to its potential health benefits. Studies have shown that it can influence the occurrence and development of various diseases such as endocrine, nervous, digestive, musculoskeletal, and respiratory disorders, as well as certain types of cancer. Additionally, it has been suggested that increasing a myosinifela abundance could be beneficial in treating these conditions. However, there are conflicting results regarding whether this bacterial species can worsen the symptoms of certain diseases, such as type 2 diabetes mellitus and neurodegenerative diseases. In order to better understand the role of A. myosinifela in these diseases, we reviewed the literature on A. myosinifela in different systemic diseases and introduced regulators of A. myosinifela abundance to facilitate the clinical application of A. myosinifela research. This article was authored by Chen Shui, Geng Laili, Sinyugu, and others.