 Proteins can be thought of as either folded or unfolded. Unfolding is a faster process than folding, but both processes are driven by energy. The rate of energy relaxation in folding is exponential, while the rate of energy dissipation in unfolding is constant. Therefore, folding is a slower process than unfolding. Folding takes approximately twice as long as unfolding, and requires more computational resources. To study folding, we propose a mathematical transformation of variables. Which allows us to view unfolding as time-reversed disassembly. This retro-fold approach can be used to reduce the computational cost of studying protein folding. This article was authored by Sergei Shichikov, Ekaterina V. Skorb and Michael Nozanovsky.