 The present study explores the phytochemical composition and biological activities of Cleomyphilina LF, Cleomaceae, using various extraction methods and analytical techniques, revealing that methanolic leaves extract exhibits significant antimicrobial and hepatoprotective efficacy, suggesting its potential use in pharmacological applications and various industries. This article was authored by Hina Yakub Sheikh, Sheikh Kalimala Niyazi, Azmatanzin Bappari, and others.