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Published on Apr 12, 2008
When cells have lots of ATP and NADH too They strive to store this energy as sugar yes they do Inside of mitochondria they start with pyruvate (slow) Carboxylating it to make oxaloacetate
Oh gluconeogenesis is so exhilarating Memorizing it can really be exasperating Liver cells require it so there's no need for debating Gluconeogenesis is so exhilarating
Oh, glucose, glucose come to be Glucose, glucose come to be
Oxaloacetate has got to turn to PEP Employing energy that comes from breaking GTP From there it goes to make a couple phosphoglycerates (slow) Exploiting ee-nolase and mutase' catalytic traits
Oh gluconeogenesis is liver's specialty Producing sugar for the body most admirably Six ATPs per glucose is the needed energy* Gluconeogenesis is liver's specialty
Oh glucose, glucose joy to me Glucose, glucose joy to me Converting phosphoglycerate to 1,3BPG Requires a phosphate that includes A-T-P energy Reduction with electrons gives us all an N-A-D (slow) And G3P's isomerized to make D-H-A-P
Oh gluconeogenesis is anabolic bliss Reversing seven mechanisms of glycolysis To do well on the final students have to learn all this Gluconeogenesis is anabolic bliss
The aldolase reaction puts together pieces so A fructose molecule is made with two phosphates in tow And one of these gets cleaved off by a fructose phosphatase (slow) Unless F2,6BP's acting blocking path-a-ways
Oh gluconeogenesis a pathway to revere That makes a ton of glucose when it kicks into high gear The cell's a masterminding metabolic engineer Gluconeogenesis a pathway to revere
From F6P to G6P, that is the final phase The enzyme catalyzing it is an isomerase Then G6P drops phosphate and a glucose it becomes (slow) Inside the tiny endoplasmic-al reticulums Oh gluconeogenesis is not so very hard I know that on the final we will not be caught off guard 'Cause our professor lets us use a filled out index card Gluconeogenesis is not so very hard
*Actually, you need two NADHs too, but that wouldn't fit the rhyme :-)
Student recording of one of Kevin Ahern's Metabolic Melodies - "Gluconeogenesis." Professional recording available for free download at