 Abstract lysosome targeting chimeras, LITACs, consisting of amphiphilic peptides linked to nanospheres, can efficiently degrade cancer cell membranes and extracellular proteins. These LITACs can be used to restore the phagocytic function of macrophages towards tumors while simultaneously reducing their toxic effects on healthy tissue. This study demonstrated the potential of these LITACs to treat cancer by combining them with glucose oxidase, an enzyme that promotes the oxidative decomposition of glucose, an anti-CD24 antibodies, which bind to CD24, a heavily glycosylated glycosyl phosphatidylenositol anchored surface protein. The results suggest that LITACs could be a powerful tool for treating cancer. This article was authored by Kun Wang, Albert Yu, Kueh Lu, and others.