 Antifospholipid syndrome, APS, is a rare autoimmune disorder which can cause multiple organ damage. It is characterized by recurring blood clots, pregnancy loss, and positive tests for antifospholipid antibodies. In this case study, a 31-year-old woman presented with symptoms of motor polyneuropathy and hand muscle weakness. She also had mitral valve regurgitation and renal dysfunction. After being diagnosed with APS, she received glucocorticoid treatment, which improved her renal function but did not improve her cardiac valvular involvement or peripheral neuropathy. This case highlights the wide range of manifestations of APS and emphasizes the importance of recognizing its presence in patients with unexplained thrombotic events and or pregnancy losses. This article was authored by Muhammad Reza Ardalan and Amir Rahidi.