 The study compares ultra-portable devices for negative pressure wound therapy by conducting a deep study of their characteristics and indications, treating 125 patients with different devices, and collecting data from scientific literature to summarize the experience and compare the devices. The results show that all ultra-portable devices have unique features, and physicians must be knowledgeable about them to provide appropriate therapy. This article was authored by Roberto Cuomo, Luca Grimaldi, Giuseppe Nysi, and others.