 educational tools for application of team science competencies in clinical research are needed. Our interdisciplinary group developed an evaluated acceptability of a virtual world game-based learning tool simulating a multi-site clinical trial, performance hinges on effective intra-team communication. Initial implementation with clinical research trainees, n equals 40, indicates high satisfaction and perceived relevance to team science and research career goals. Game-based learning may play an important role in team science training. This article was authored by Colin A. Depp, Alex Howland, Jill Dumbled, and others.