 Standardized extracts of undenatured type 2 collagen, UC2, have been shown to be effective in treating osteoarthritis, OA, reducing inflammation and pain. These extracts work by modulating the body's immune system, decreasing the production of pro-inflammatory cytokines and prostaglandins, and interacting with discoidin receptors to promote cartilage repair and reduce pain. Clinical trials have demonstrated the efficacy of these extracts in improving symptoms of OA and subclinical joint dysfunction. This article was authored by OA Grimova, IU Torsion, AM Lila, and others.