Table of Contents:
00:09 Lecture 3.1: Nanobiosensors Sensitivity and Types of Biosensors
02:10 Outline
03:24 The importance of sensitivity
04:51 Part 1: Geometry of diffusion
06:03 Sensitivity defined by detection mechanism
08:07 Types of sensors: tags vs. transducer
09:16 Three types of sensors
10:10 A short history of Potentiometric sensors
11:24 Transistor physics (potentiometric sensor)
15:25 Sensitivity of a MOSFET-based potentiometric sensor
16:45 How does a potentiometric Field Effect Transistor work (accumulation)
18:38 Recall from Lecture 3: Sensitivity Gain
20:05 Concentration dependence
22:26 Puzzle of Concentration dependence
24:06 Evolution of a MOSFET
25:44 DNA binding and Salt screening
27:58 The classical theory does not work ...
28:47 Conclusions
This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors". (https://nanohub.org/courses/PEN)
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.
For more details see http://nanohub.org/u
