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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 3.1: Nanobiosensors Sensitivity and Types of Biosensors 02:10 Outline 03:24 The importance of sensitivity 04:51 Part 1: Geometry of diffusion 06:03 Sensitivity defined by detection mechanism 08:07 Types of sensors: tags vs. transducer 09:16 Three types of sensors 10:10 A short history of Potentiometric sensors 11:24 Transistor physics (potentiometric sensor) 15:25 Sensitivity of a MOSFET-based potentiometric sensor 16:45 How does a potentiometric Field Effect Transistor work (accumulation) 18:38 Recall from Lecture 3: Sensitivity Gain 20:05 Concentration dependence 22:26 Puzzle of Concentration dependence 24:06 Evolution of a MOSFET 25:44 DNA binding and Salt screening 27:58 The classical theory does not work ... 28:47 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.