 Nanoparticles, end-piece, have many potential applications in biology and medicine, but their use has been limited by the fact that they tend to aggregate in solutions with high ion extremes. Additionally, when exposed to certain biological fluids such as those containing proteins, end-piece can become coated with these proteins, which can interfere with their functioning. To address these issues, researchers have developed several strategies to stabilize end-piece in high ionic strength environments and prevent them from being covered with proteins. These strategies include using surfactants or polymeric coatings to reduce the surface charge of the particles, adding organic solvents to the solution, and using antifouling agents to block protein adsorption. This article was authored by Luca Gurini, Ramone Alvarez Puebla, and Nicolas Pazosparez.