 This study examined the mediating role of self-confidence and family cohesion and depression in adolescence. The results showed that there was a significant positive association between family cohesion and self-confidence, as well as a significant negative association between family cohesion and self-confidence with depression. Additionally, the mediation analysis revealed that self-confidence partially mediated the relationship between family cohesion and depression. This suggests that early and timely identification of risk factors such as low self-confidence could help prevent serious consequences of depression in adolescence. This article was authored by Saeeda Taskin-Zara, Saudia Saleem and Admin.