 Tick-borne encephalitis, TBE, is most effectively prevented through vaccination with either a rapid 0,721 days, or conventional 0,28-84 days, 9-12 months, 3-dose primary schedule. The second dose can also be administered at 14 days for faster priming and seroprotection. A single booster dose induces a strong immune response in all subjects irrespective of primary vaccination schedule or elapsed time since priming, with GMT peaking at 42 days post-dose one. Adverse events are generally rare and decline with increasing doses. This article was authored by Eloria Galgani, Evelyn M. Bunch, Lisa Hendricks, and others.