 What I should have said was, we don't necessarily want you or anyone else controlling our thought process, rather than you. If we control your brains, we control your thoughts. Many can make me want it. Is that good? I understand. Lizard's A World Health Report was published at the end of the last century predicting what the major diseases were going to be affecting the world. And number three is major depression. Not in terms of killing people, but certainly on their lifestyle and their morbidities or the downstream consequences of being depressed makes you more likely to get diseases, makes you more likely to die from other things and so on. It's a major, major health problem. And then the question is how do you actually go about improving that situation and what approaches do you have? So the way in which we try to understand how brains produce illness, how brains produce behaviour is at the level of the circuits within them. And whereas in the past, people had ideas about a bad thing happening due to a Sigmund Freud-type analysis of brain function, it would be due to some experience you had. And more recently we've been using genetic approaches to understand what might predispose you to an illness. What we're trying now to do is say that these problems arise from brain activity. So let me take an example. We've done some genetic work where we think that a set of genes involved in actin depolymerisation is involved in motion. So it's not clear why something as basic as that would be involved in the brain in emotional regulation. So we actually thought, well, could we find it in flies? So this is so basic, would you find it in a fly brain? We do find it in a fly brain. The fly has this particular gene, has this particular enzyme. So then we just have to test whether the fly gets a bit upset if we manipulate that part of its cellular structure. And we can do that in flies because we couldn't do that in humans and it's very difficult to do it in mammals, but cheap and easy relatively to do it in flies. So we do that manipulation and lo and behold we find unexpected change. So you'll see in a moment two flies. In one fly we've genetically engineered the neurons that make it fly so that when we turn a laser light on the fly will fly away. While it's mate who does not have light responsive neurons will stay behind. So watch for the flash of light. So this works well in flies where the light can get into the brain but not so well in mammals because we have a skull. So there you've moved from thinking about a problem on a rather global scale, having insight into whether it's a structural or functional process that might be conserved and then test that hypothesis directly in a model organism. So you need those resources to answer these questions. We're going to have you grab the chairs, move yourselves close enough to the board to really be part of the conversation. There can be no one who doesn't have a certain degree of discomfort. Most of the people here are supportive of all advances in technology. We're not trying to stop learning. But you must confront this on a daily or at least monthly basis. We want to control brains. Our problem is that brains don't want to be controlled. So we have to overcome this barrier that brains have inherently that they can't be controlled. No, we definitely want to control brains. What I've given you is a totally overblown description of what's possible. The moment you got that, so the moment all we can do is make a mouse run around and that's about as best as it gets. No, it's a little bit better. We can make him go to sleep. So you can put a light into a part of the brain and then it'll fall asleep and it'll wake up. But in order to do anything more sophisticated than that, I mean it's just, we're at the very, very beginning. I've got that initial problem and then I've got the problem that the biology is horrendously complicated. We only know a fraction of what's going on in brains. We don't really know how they work. We don't know how they produce feelings. And without knowing that information, how can I understand what's going wrong in somebody's brain? So put those things together and you have one of the most challenging problems in biology.