 Bionic scaffolds are a promising solution for repairing bone defects, but it is difficult to fabricate scaffolds with bionic structures and reconstruct the micro-environment to fulfill satisfying repair effects. Strategies for designing and constructing bionic scaffolds include structural construction, integration of bioactive substances, and application of external stimuli. Artificial intelligence and medical imaging can aid clinical treatment. Challenges in developing multifunctional bone repair scaffolds include improving regeneration efficacy and accelerating clinical translation. This article was authored by Jen Song, Longfei Li, Lei Fang, and others.