 The National Dental Practice Based Research Network, PDPRN, was established in 2005 as a multi-regional practice-based research network, PBRN. In 2012, it expanded nationwide and in 2019 implemented additional organizational changes. The goal of this network is to provide a platform for researchers to conduct practice-based research on a large scale. Since its inception, the PDPRN has conducted over 58 studies involving more than 70,000 patients and 20,000 dental professionals. Additionally, the PDPRN has published 193 peer-reviewed papers in 62 different journals, demonstrating a higher-than-average citation rate. This article was authored by Greg H. Gilbert, Geoffrey L. Fellows, Vera Sathpurush-Alaredi, and others.