 Theoretical calculations predicted that functional groups on graphing quantum dots, GQDs, can enhance the formation of MOS2 nano sheets, and a functionalized GQD-induced in-situ bottom-up approach was used to synthesize near atom layer QD at SO3 with about 2 nanometers. Electron withdrawing group functionalized GQDs facilitate the formation of MOS2 nano sheet architectures compared to electron donating group. This article was authored by Bingjie Hu, Kai Huang, Biju and Tang, and others.