 Nanosilver has unique properties that make it potentially more toxic than bulk silver due to its small particle size and high-surface area. These particles can reach subcellular locations, leading to higher localized concentrations of ions once they dissolve or degrade in situ. Nanoparticles can also generate reactive oxygen species and interact with biomolecules such as proteins, enzymes, and DNA. The nanoparticle size, shape, surface coating, and other factors contribute to these interactions, making it difficult to predict toxicity. To assess the environmental and biological impacts of silver nanoparticles, future studies should provide detailed descriptions of the particle synthesis route, stabilization mechanisms, coating, and evolution under exposure conditions. A risk-benefit analysis is needed for all applications, and restrictions may be necessary where a clear benefit cannot be demonstrated. This article was authored by Assault Lynch, Kenneth A. Dawson, Andreas Lutch, and others. We are article.tv, links in the description below.