 Hi, I am Dr. Ravichan Siddhachari. I am a consultant hepatobiliary and liver transplant surgeon for Manipal Hospital Group, Bangalore. Liver transplantation is necessary for end-stage liver disease or it is also called as cirrhosis or chronic liver disease with decompensation. So the causes are many but the common causes in India are hepatitis infection such as hepatitis A, B, C and E. In this hepatitis A and E usually causes acute liver failure and B and C usually causes chronic liver failure. Now other causes are alcoholic liver disease which is very common in India and then you have something called non-alcoholic liver diseases or fatty liver going into cirrhosis. So these are the most common causes and there are other causes like autoimmune liver disease, primary sclerosis in colonitis and some hereditary diseases which can also lead to liver cirrhosis. So the hereditary conditions which lead to liver cirrhosis or something called Wilson's disease or the copper accumulation in the liver and the second one is hemochromatosis where the iron accumulates in the liver which causes the damage to the liver. There are some conditions which cause liver failure in the kids which is called biliri atresia where there is a blockage to the bile duct and other conditions are glycogen storage disease. These are the metabolic conditions which is due to the deficiency of an enzyme in the children.