 This study developed a new technique for analyzing protein interactions within mitochondria, which is important for understanding how these organelles function. The researchers used nanoparticles to deliver protein cross-linkers into mitochondria, allowing them to detect and analyze the interactions between proteins. This approach was found to be highly successful, with 74% of the interactions detected being consistent with existing knowledge about the structure of the proteins involved. Furthermore, the researchers were able to identify interactions between proteins that had not been previously identified in databases such as String. Overall, this study provides a powerful tool for studying protein interactions within mitochondria, providing valuable insight into the inner workings of these essential organelles. This article was authored by Yuan Chen, Wenju, Euphatia, and others.