 Antibiotic resistance genes, arches, have accelerated microbial threats to human health. Here, Jong et al. Analyze 4,572 metagenomic samples to illustrate the global patterns of ARG distribution in diverse habitats. They quantitatively evaluate the health risk to humans of 2,561 arches by integrating human accessibility, mobility, pathogenicity and clinical availability. With the machine learning, they map the antibiotic resistance threats in global marine habitats. This article was authored by Jinyin Jong, Qi Zhong, Ting Zhong Wang, and others.