 This research investigates the genomic features associated with esophageal adenococenoma, a poor prognosis cancer. It identifies two distinct patient groups based on their genomic profiles, one which has a poorer prognosis and another which has a better prognosis. This suggests that certain genomic features are linked to the disease's progression and could be used to identify patients who would benefit from immunotherapies. This article was authored by Mojohn M. Nini, Felicity Newell, Lauren G. Aude, and others.