 ED1 is a key component of clathrin-mediated endocytosis, which is a process by which cells take in nutrients from their environment. It has been shown to be important for the formation of endosomes, but how it does this was not understood until now. This research used fluorescent cross-correlation spectroscopy to detect interactions between ED1 and other proteins involved in endocytosis. They found that ED1 forms oligomas in the cytoplasm, which are necessary for its localization to the endocytic site. Additionally, they showed that these oligomas are linked to ED1's ability to concentrate endocytic adapters and organize the endocytic machinery. This research provides insight into the regulation of protein-protein interactions in the cytoplasm, which is essential for the proper functioning of endocytosis. This article was authored by Dominic Bogue, Suzanne Trotman, Matthias Mira, and others.